Pharmaceutica Analytica Acta

Comparative study of superdisintegrants on formulation and design of directly compressible oral fast dissolving tablets of Venlafaxine HCL: An in-vitro and ex-vivo study

4^th International Conference and Exhibition on Pharmaceutics & Novel Drug Delivery Systems

March 24-26, 2014 Hilton San Antonio Airport, San Antonio, USA

Mokale Vinod J, Naik Jitendra B, Patil Ajit P, Patil Harshada I and Jadhav Dhananjay S

Accepted Abstracts: Pharmaceut Anal Acta

Abstract:

The main purpose or aim of the present study was to formulate and evaluate Oral Fast Dissolving Venlafaxine HCl tablets (OFDV): Comparative study of different superdisintegrants with various concentrations by direct compression method, which is simple and cost effective method. Venlafaxine HCl is an antidepressant drug to evade the first pass metabolism. Six formulations by using synthetic disintegrants and six by using natural disintegrants in all twelve formulations were conducted for the selection of optimal concentration of superdisintegrant. Oral Fast Dissolving Venlafaxine HCl tablets were evaluated for various pre and post compression parameters like FTIR, XRD, FESEM, particle size analysis, in-vitro dissolution and ex-vivo permeation study. The optimum formulation chosen and their best possible results were found to be in close agreement with experimental verdict. The batches prepared by using natural disintegrants shown better bioavailability and release profile based upon ex-vivo and in-vivo studies respectively. Above all studies revealed that fast dissolving tablet using synthetic disintegrants can be successfully replaced by using natural disintegrants retaining all the parameters.