Oral Health and Dental Management

Clinical applications of gingival stem cell derived extracellular matrix

4^th Asia Pacific Congress & Expo on Dental and Oral Health

July 27-29, 2015 Brisbane, Australia

Yi-Hao Huang

Posters-Accepted Abstracts: Oral Health Dent Manag

Abstract:

Mesenchymal stem cells (MSCs) are defined as undifferentiated cells that are capable of self- renewal and differentiate into several cell types such as chondrocyte, adipocyte, osteocyte, myocyte, hepatocyte and neuron-like cells. Moreover, MSCs express several extracellular matrix (ECM) molecules such as collagen, fibronectin, laminin, and proteoglycans. Our research team aims to accelerate the translation of laboratory research from stem cell and molecular biology into the clinical regenerative medicine. It is the first time that a novel injectable bio-graft which composed of MSCs (gingival stem cells), bone cement (calcium sulfate powder) and stem cell bone bioliquid was developed for the applications of bone regeneration. In the animal model, we can engineer a scaled-up ossified tissue with features of a ?bone organ,? including physiologically cortical bone, mature vasculature and a hematopoietic compartment by using the injectable bio-graft. This work provides a model helpful for the applications of translational bone regeneration on the alveolar bone augmentation in dental implant surgery. The ECM from the stem cells act as cell languages that can signal the resident cells to behalf the way we want it to be. In the most updated data, no stem cells are needed to do tissue engineering. Stem cell derived ECM alone can work efficiently as regenerative medicine. Without using stem cell directly in regenerative surgeries, the ECM can be manufactured in industrialized scale and used by general public.