Badria Al Matrafi
Prince Sultan Military Medical City, KSA
Posters & Accepted Abstracts: Oral Health Dent Manag
Metronidazole is nitroimidazole antibiotic medication which has a specific activity against anaerobic bacteria and protozoa. In cardiology, the QT interval represents electrical depolarization and repolarization of the ventricles. A lengthened QT interval is a marker for the potential of ventricular tachyarrhythmia. Rare cases have been reported with QT prolongation in which metronidazole antibiotic had been used. The arrythmogenic property of Metronidazole is not yet clear. This case reports a 10 year old male child of 30 kg body weight with no history of any chronic illness or drug allergy came to the dental clinic with facial swelling, which was diagnosed as dental abscess. He was given oral Metronidazole (500 mg 3 times a day for 5 days). On the third day, he presented to the emergency department with palpitation, vomiting and then he collapsed. Cardiac Pulmonary Recitation (CPR) done and Electrocardiogram (ECG) showed prolonged QT corrected interval (QTc 480 ms). Laboratory test including serum potassium, magnesium and liver functional tests were within normal. Metronidazole was immediately stopped and subsequently the ECG retained to normal. In conclusion, Metronidazole can potentiate QT prolongation. Further investigation should be carried out to assess its potential effect on QT interval and subsequent lethal arrhythmias. The maximum pediatric dose should be reviewed.
Badria Al Matrafi has completed her BDS in 1991 in King Saud University in Riyadh KSA and AGD certificate in 2000 from University of South California, USA. She is a Consultant Restorative Dentistry in Prince Sultan Military Medical City in Riyadh. She is the Director of dental clinic and has a year of teaching and clinical supervision experience.