Oral Health and Dental Management

BonoFill - A Novel Treatment for Maxillofacial Bone Tissue Regeneration

18^th International Conference on Oral Health & Maxillofacial Surgery

December 05-06, 2016 Madrid, Spain

Ephraim Tzur

Assaf Harofeh Medical Center, Israel

Scientific Tracks Abstracts: Oral Health Dent Manag

Abstract:

Over recent years, we have developed a three-dimensional, high-density bone graft designed to overcome the limitations associated with current bone reconstruction treatments. The graft, named BonoFillTM, is generated from the patients' adipose tissue-derived cells, and consists of a heterogeneous cell population, providing superior osteinductive properties and promoting graft integration and de novo bone formation. Produced in Bonus Biogroup's GMP-certified clean room facility, BonoFillTM represents a potent therapeutic modality for bone repair. A phase 1/2 open label first-in-human clinical study was performed to evaluate the safety and efficacy of BonoFillTM as a bone graft for reconstructing maxillofacial bone tissue in two clinical indications: �?� Bone augmentation �?� Bone grafting Eleven eligible male and female subjects aged 49-65 years were enrolled and underwent the BonoFillTM treatment. Clinical follow-up was performed throughout a period of 20-27 months and included X-rays, CT scans and biopsies collected from the transplantation site. The study was conducted in MY Medical Center, Israel, under regulatory approval and in compliance with the ICH-GCP guidelines . Results of the study demonstrate that BonoFillTM promoted fast and high quality bone tissue regeneration without complications. There was no chronic bone infection (Osteomyelitis), no significant changes in complete blood count (CBC) and in the subject's general health. The newly-generated bone was of high density and provided stable support for dental implants. To conclude, BonoFillTM is a promising novel solution for bone repair, which will be further studied in additional clinical settings.

Biography :

Ephraim Tzur is a senior periodontal surgeon specializing in implant surgery and cranio-maxillofacial rehabilitation and is the former Director of the Oral & Maxillofacial Surgery Unit at Assaf Harofeh Medical Center, Israel. He earned his medical degree from Hadassah University School and is board certified by the Israeli Board of Dental Surgeons. Dr. Tzur is a member of the Israeli and American Oral and Maxillofacial Surgeons. He has over 30 years of experience in all aspects of reconstruction and rehabilitation of hard and soft tissue defects of the oral cavity, jaws and facial structures. He is actively involved in dent-alveolar surgery, orthogenetic surgery for the treatment of congenital and developmental deformities, reconstruction of disease and trauma-induced defects and in dental implantology for the regeneration and restoration of the jawbones.

Email: drorbd@bonus-bio.com