Oral Health and Dental Management

Bone formation using autologous biomaterials combined with synthetic bone substitutes: Practical tools for successful implantation

International Conference and Exhibition on Dentistry

March 18-20, 2015 Dubai, UAE

Dmitry Bulgin and EnesHodzic

Posters-Accepted Abstracts: Oral Health Dent Manag

Abstract:

Replacing missing bone or adding mass to existing bone is often essential to the success of a dental implant. An implant needs a critical mass of bone surrounding it in order to bind to it and deliver sufficient strength and stability. If in the location where the implants are intended there is low mass of bone (width or height) a bone graft must be applied in order to maintain this critical bone mass. A large variety of graft materials have been used for maxillary and mandibular atrophy. Autologous biomaterials enriched with progenitor/stem cells and growthfactors can be produced from components of bone marrow, peripheral blood, adipose tissue, cancellous bone, and represent a very interesting research field for dental bone regeneration and suppose a good perspective of the future in the clinical dentistry. The adjunctive clinical benefit of the autologous biomaterials preparation can be explained on the basis of tissue engineering, i.e., tissue engineering generally combines three key elements for regeneration: 1) scaffolds or matrices, 2) signaling molecules or growth factors, and 3) cells. Stem cells need a scaffolds that facility their integration, differentiation, matrix synthesis and promote multiple specific interactions between cells. Synthetic or artificially designed substitutes has numerous interconnecting pathways similar to cancellous bone and facilitates bone formation by providing an exceptional osteoconductive scaffolding which results from the retention of the natural porous architecture and trabeculation of human cancellous bone. Synthetic scaffolds show resorbable characters during bone regeneration, and can be completely substituted for the bone tissue after stimulation of bone formation. The use of autologous biomaterials combined with synthetic scaffolds is a recent and promising innovation in dental bone regeneration.Our experience with autologous biomaterials combined with artificially designed scaffolds for augmentation of the extremely atrophic maxilla and mandible is presented.The techniques are based on stimulation of natural events continuously present in living bone, that is, the process of bone remodeling and offering both osteoinduction and osteoconductive features.