Biochemistry & Analytical Biochemistry

Association between hypertriglyceridemia and protein oxidation and pro-inflammatory markers in normocholesterolemic and hypercholesterolemic individuals

International Conference on Clinical Chemistry & Laboratory Medicine

October 17-18, 2016 Chicago, USA

Jonatas Zeni Klafke and Paulo Ricardo Nazario Viecili

Universidade de Cruz Alta, Brazil

Posters & Accepted Abstracts: Biochem Anal Biochem

Abstract:

Background: Although hypercholesterolemia is a well-established risk factor for coronary heart disease, evidence suggests that elevated triglyceride (TG) levels are also an independent risk factor. TG levels above 150 mg/dL are observed nearly twice as often in subjects with atherosclerosis. Aim: The major aim of this work was to assess the association between hypertriglyceridemia and protein oxidation and proinflammatory markers in normocholesterolemic and hypercholesterolemic individuals. Design & Methods: This study included 127 volunteers enrolled in Cruz Alta, RS, Brazil. The patients were stratified based on total cholesterol and TG levels for analysis of associations with inflammation (high-sensitivity C-reactive protein-hs-CRP), endothelial dysfunction (nitric oxide-NOx) and oxidative stress (advanced oxidation protein products-AOPPs; ischemia-modified albumin- IMA). Correlations between variables were determined and multiple regression analysis was employed to investigate whether some variables correlate with TG concentrations. Results: Hypertriglyceridemia was related to oxidative stress and proinflammatory markers in individuals independent of total cholesterol levels. Moreover, the results indicate a stronger association of tested biomarkers with TG levels than with total cholesterol. The results indicate a positive correlation between oxidative stress and TG levels in the sera of hypercholesterolemia subjects. AOPPs and IMA concentrations were associated with the presence of hypertriglyceridemia in a manner that was independent of age, gender, hypertension and diabetes mellitus disease, smoking habits, sedentary lifestyle, BMI, waist circumference, LDL, HDL and total cholesterol levels. Conclusions: We speculate that TG levels can reflect the enhancement of protein oxidation and pro-inflammation.

Biography :

Email: jonzeni@hotmail.com