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AFM investigation of DNA and their interaction with MCM protein complex
7th World Nano Conference
June 20-21, 2016 Cape Town, South Africa
Amna Abdalla Mohammed Khalid
Trieste University, Italy
Scientific Tracks Abstracts: J Nanomed Nanotechnol
Abstract:
We are interested to study helicase connected to replication process in eukaryotic: is MCM (mini chromosome maintenance) complex, six homologous MCM proteins known as MCM2-7, which form a ring that is supposed to �??load�?� onto the DNA using energy produced by ATP hydrolysis and move across unwinding the double helix. In this study we used archaeal MCM from Methanothermobacterthermautotrophicusas a model system. Our main idea is to investigate the conformational changes of the DNA deposited on a mica surface upon the interaction with MCM proteins by means of AFM imaging. Based on structural and biochemical evidences, two modes of MCM-DNA interaction have been proposed. The canonical mode where the MCM protein complex is encircling the DNA and is thus �??loaded�?� onto DNA ready for unwinding. A second mode of interaction called associated MCM, where the DNA is wrapped around the external part of the proper ring structure.
Biography :
Amna Abdalla Mohammed Khalid has completed her PhD from Trieste University (Nanotechnology school). She is currently a research fellow at Nano innovation lab in Elettra- Sincrotrone Trieste. Moreover she is Next Einstein forum ambassador of Sudan.