Inactivation of P16 (INK4a) Gene by Promoter Hypermethylation is Associated with Disease Progression in Chronic Myelogenous Leukaemia

Imtiyaz Ah^1#, Mir Rashid^1#, Sameer G¹, Jamsheed J¹, Mariyam Z¹, Shazia F¹, Prasant Y¹, Masroor M¹, Ajaz Bhat², Sheikh Ishfaq³, Naveen Kumar⁴, Khalani T⁵, Naresh Gupta⁶, P C Ray¹ and Alpana Saxena^1*

¹Cancer Genetics Lab, Department of Biochemistry, Maulana Azad Medical College and Associated hospitals, New Delhi, India

²Division of Surgical Oncology, Vanderbilt University, Nashville, TN, USA

³King Fahd Medical Research Center, King Abdulaziz University, Kingdom of Saudi Arabia

⁴Department of Oncopathology, ACH, Delhi, India

⁵Department of Medicine, BCM, Texas, India

⁶Department of Medicine, MAMC and LN hospital, New Delhi, India

^#Contributed equally to this work