Journal of Carcinogenesis & Mutagenesis

Ajaz Bhat

Publications

• Research Article
  Inactivation of P16 (INK4a) Gene by Promoter Hypermethylation is Associated with Disease Progression in Chronic Myelogenous Leukaemia
  Author(s): Imtiyaz Ah, Mir Rashid, Sameer G, Jamsheed J, Mariyam Z, Shazia F, Prasant Y, Masroor M, Ajaz Bhat, Sheikh Ishfaq, Naveen Kumar, Khalani T, Naresh Gupta, P C Ray and Alpana SaxenaImtiyaz Ah, Mir Rashid, Sameer G, Jamsheed J, Mariyam Z, Shazia F, Prasant Y, Masroor M, Ajaz Bhat, Sheikh Ishfaq, Naveen Kumar, Khalani T, Naresh Gupta, P C Ray and Alpana Saxena
  
  Background: Chronic Myelogenous Leukemia (CML) has a typical progressive course with transition from a chronic phase to a terminal blast crisis phase. The mechanisms that lead to disease progression remain to be elucidated. Promoter hypermethylation is one of the putative mechanisms underlying the inactivation of negative cell-cycle regulators in haematological malignancies. Therefore, aim of our study was to examine whether the methylation status of P16 (INK4a) gene is a useful biomarker in the development and progression of CML.Material and Methods: The methylation status of p16INK4A gene was evaluated by Methylation Specific Polymerase Chain Reaction (MSP) in 200 CML patients among which, 81 were in CP-CML, 54 in AP-CML and 65 in BC-CML.Results: The p16INK4A gene was hypermethylated in 84 of 200 (42%) of CML patients (P.. View More»
  DOI: 10.4172/2157-2518.1000141

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