Exposure to Reactive Oxygen Species and Piperacillin Leads to Multidrug Resistance in Pseudomonas aeruginosa PAO1

Sachiko Hayakawa^1,2*, Emiko Furukawa¹, Masato Kawamura¹, Toshiaki Kikuchi³, Taizou Hirano⁴, Akira Watanabe⁵ and Shigeru Fujimura^1,5

¹Division of Clinical Infectious Disease & Chemotherapy, Tohoku Medical and Pharmaceutical University, Sendai, Japan

²Department of Pharmacy, Tohoku Medical and Pharmaceutical University Hospital, Sendai, Japan

³Department of Respiratory Medicine and Infectious Diseases, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan

⁴Department of Respiratory, Tohoku University Graduate School of Medicine, Sendai, Japan

⁵Resarch Division of Development of Anti-Infective Agents, Institute of Development Aging and Cancer, Tohoku University, Sendai, Japan