Effects of Thujaplicins on the Promoter Activities of the Human SIRT1 and Telomere Maintenance Factor Encoding Genes

Fumiaki Uchiumi^1,2, Haruki Tachibana³, Hideaki Abe⁴, Atsushi Yoshimori⁵, Takanori Kamiya⁴, Makoto Fujikawa³, Steven Larsen², Shigeo Ebizuka⁴ and Sei-ichi Tanuma^2,3,6,7*

¹Department of Gene Regulation, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Noda-shi, Chiba-ken 278-8510, Japan, E-mail: uchiumi@rs.noda.tus.ac.jp

²Research Center for RNA Science, RIST, Tokyo University of Science, Noda-shi, Chiba-ken, Japan, E-mail: uchiumi@rs.noda.tus.ac.jp

³Department of Biochemistry, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Noda-shi, Chiba-ken 278-8510, Japan, E-mail: uchiumi@rs.noda.tus.ac.jp

⁴Hinoki Shinyaku Co., Ltd, 9-6 Nibancho, Chiyoda-ku, Tokyo 102-0084, Japan, E-mail: uchiumi@rs.noda.tus.ac.jp

⁵Institute for Theoretical Medicine, Inc., 4259-3 Nagatsuda-cho, Midori-ku, Yokohama 226-8510, Japan, E-mail: uchiumi@rs.noda.tus.ac.jp

⁶Genome and Drug Research Center, Tokyo University of Science, Noda-shi, Chiba-ken 278-8510, Japan, E-mail: uchiumi@rs.noda.tus.ac.jp

⁷Drug Creation Frontier Research Center, RIST, Tokyo University of Science, Noda-shi, Chiba-ken 278-8510, Japan, E-mail: uchiumi@rs.noda.tus.ac.jp