Professor, Histology & General Embryology
University of Rome, La Sapienza, Italy
Dr. Sergio is working as a Professor of Histology & General Embryology at Sapienza University of Rome, Italy. He received his MD degree at University of Rome in the year of 1974. He had been Post Doctoral Fellow at University of Rome from 1974 to 1975. He served as a Visiting Fellow at NCI, NIH and Bethesda from 1976 to 1978. From 1982 to 1986 he served as an Associate Professor at University of Rome Medical School. In 1988 he was honoured as Professor at University of L Aquila Medical School. In 2002 he was appointed as Vice President of the Dental School at "La Sapienza" University of Rome. Currently he is serving as a Professor and Coordinator of PhD program in Morphogenetic and Cytological Sciences at "Sapienza" University of Rome, Italy. He is author and Co-author of over 70 full papers on high quality peer-reviewed journals, including J. Natl. Cancer Inst., J. Cell Biol., Blood, J. Biol. Chem., Mol. Biol. Cell, Stem Cells, etc.
Muscle regeneration - Muscle homeostasis: hypertrophy, atrophy, cachexia
Myogenic differentiation in culture - - Hormonal control of cell proliferation and differentiation - Vasopressin and IGF role in myogenesis - Signal transduction - Biological effects of retinoids on normal and transformed cells.
The research interests have focused on the mechanisms controlling myogenic cell differentiation and their alterations in dystrophic, transformed and aged muscle. Most relevant results indicate that factors such as vasopressin, IGF1, TNF, through their respective signaling pathways, play a role on the transcriptional control of MRF(MyoD, myogenin, MEF2) in normal and diseased muscle. We have shown that vasopressin, through the activation of the calcineurin- and the CaMK- dependent pathways, induces the formation of multiple transcription factor complexes. We are currently investigating the mechanisms controlling muscle homeostasis and their modifications by agents inducing hypertrophy (AVP), as well as senile or disuse atrophy and cachexia (TNF), and the role of intra- and extra-muscular myogenic precursors in such processes.