Associate Professor, Department of Environmental Toxicology
University of California, USA
Currently I am Associate Professor for Research in the Department of Environmental Toxicology at the University of California in Davis USAI have received my MSc and PhD at the University of Duesseldorf in Germany in Molecular Biology and Biochemistry in 1996. I was trained in Experimental Toxicology at the Medical Institute of Environmental Hygiene at the HeinrichHeineUniversity Duesseldorf Germany. In 1999 I certified as an Expert Toxicologist by the Society of Pharmacology and Toxicology in Germany. In 2000 I joined the Department of Environmental Toxicology and Center for Health and the Environment at UC Davis.The interaction of AhR and RelB is also the focus of my research project investigating the contribution of environmental exposure for the development of breast cancer. Recent papers are demonstrating that certain cytokines and chemokines especially IL8 together with RelB are significantly overexpressed in inflammatory type of breast cancer.
Role of environmental toxicants like polycyclic aromatic hydrocarbons (PAHs) in the carcinogenic action of non-Hodgkin lymphoma (NHL). The long-term objective of this study is to achieve a better understanding of the mechanistic action of the development of lymphoma, which is responsible for a higher incidence of these cancer diseases in humans exposed to environmental risk factors like dioxins and polychlorinated biphenyls (PCBs). Focus of this study is the suppression of apoptosis and transcriptional regulation of relevant target genes in the inflammatory response through the Aryl hydrocarbon Receptor (AhR) and NF-kappaB.