Associate Professor, Pathology
University of Rome, University of Rome La Sapienza, Italy
Pathologist, Cytopathology Unit, USL RM2 Rome (1992-3); Chief, Clinical Pathology Section, Department of Molecular Pathology, Istituto di Ricovero e Cura a Carattere Scientifico NEUROMED (1993-2000); Associate Professor in General Pathology and Pathophysiology, University of Rome La Sapienza, Faculty of Medicine (2001); Chief, Diagnostic Unit of Molecular Pathology, ASL Latina (2005).Chief of Molecular Oncology Laboratory University of Rome La Sapienza, Faculty of Medicine Latina Polo Pontino
To investigate the biologic mechanisms involved in neoplastic growth.
The research activity was oriented to define morphological and functional alterations in hematological neoplasia and gliomas . Main research interests during the last years were focused on the study of Egr-1 protein and its role in the control of cell apoptosis and proliferation .These studies applied to either human lymphocytes or CNS cells showing the role for Egr-1 as gene able to regulate cell proliferation and apoptosis in the EBV-positive lymphomas and, more recently, the glial tumors. The role for Egr-1 as apoptotic co-regulator in cerebellar granular cells was also demonstrated.Recently we have demonstrate a correlation between EGR1 expression and response to cisplatin in glioma primary cells.We have also demonstrated in collaboration with Prof A Tata and Prof F. Franciolini (University of Perugia) the role of M2 receptors in gliomas and the involvement of ion channel KCNN4 in the glioma cell motility.