Journal of Vaccines & Vaccination

Department of Toxicology, Key Laboratory of Modern Toxicology of Shenzhen, Shenzhen Center for Disease Control and Prevention, Shenzhen 518055, China

Publications

• Research Article   
  Effect of Storage Temperature on the Quality Stability of Nanoparticle Aluminum Hydroxide Adjuvant
  Author(s): Xifei Yang and Feiwei Zhang*
  
  The aluminum hydroxide adjuvant exhibits a Poorly Crystalline Boehmite (PCB) structure, which is influenced by storage conditions. In this research, we comprehensively disclosed the alterations in the crystal structure, combination conventional quality indicators of the adjuvant during storage under different temperature conditions. Three batches of aluminum hydroxide adjuvants were respectively stored at 2-8°C, 18-25°C, and 37°C for 6 months. We detected the X-ray diffraction, pH, Isoelectric point (pI), adsorption rate, and average particle size of the adjuvants. X-ray diffraction revealed that the aluminum hydroxide adjuvants were PCB. After being stored at 37°C for 1 months, new diffraction peaks emerged at 18.2° 2θ in the diffract grams of the adjuvants, and the peak intensity increased along with the extension of the storage time. Meanwhile, the decreas.. View more»
  

  Abstract PDF