Clinical & Medical Biochemistry

Department of Laboratory Medicine, University Hospital of Udine, Udine, Italy

Publications

• Research Article   
  Adrenomedullin in Cerebrospinal Fluid: Potential Role in Central Nervous System Diseases and Reliable Measure Using an Automated Method
  Author(s): Furlani Matteo, Visentini Daniela, Pesente Fiorenza, Cussigh Anna Rosa, Janes Francesco, Tascini Carlo, Curcio Francesco and Fabris Martina*
  
  Background and aim: Adrenomedullin (ADM) is a potent hormone-like peptide induced by hypoxia and inflammatory cytokines, that exerts an important vasodilation effect, which resulted protective in case of myocardial infarction and brain injuries. ADM is rapidly induced in the initial stages of sepsis, so the dosage of its more stable precursor fragment called Mid-Regional (MR)-proADM is currently recommended to assist triaging of patients suspected for sepsis in the emergency department. Much more limited is its use in the context of neurological disease, since its dosage is only certified in plasma. In this report we highlighted ADM functions in neurological pathophysiology in order to support the importance of its dosage also in the Cerebrospinal Fluid (CSF). Methods: MR-proADM concentrations were measured samples using a fully automated pl.. View more»
  

  Abstract PDF