Journal of Allergy & Therapy

Immunology Discovery, Abbvie Inc., North Waukegan Road, North Chicago, IL 60064, USA

Publications

• Review Article   
  Cellular, Molecular, and Pharmacological Characterization of a House Dust Mites (HDM)-Induced Murine Model of Dermatitis
  Author(s): Zhi Su, Samrawit Aforki, Zachary K. Goldsmith, Sheila Cummings, Kathleen M. Smith, Xin Chen, Stacy H. Ryu, Anastasia E. Marinopoulos, Joseph B. Wetter, Samuel Karsen, Gunarso Nguyen, Nancy Crosbie, Laura Wasserman, Elizabeth Asque, Gricelda Simler, Stephanie E. Paulsboe, Samantha Ciura, Danyal Butt, Heath A. McDonald, Ramkrishna Sadhukhan, Viktor Todorovic, Victoria E. Scott and Jacqueline Loud*
  
  Background: House Dust Mites (HDM), common allergens that can induce Atopic Dermatitis (AD), are widely employed to generate mouse models of AD. In the current study, we compared the AD-like phenotypes between two mouse strains, NC/Nga, and BALB/c, in response to HDM, and performed cellular, molecular, and pharmacological characterization of HDM-induced dermatitis in NC/Nga mice. Methods: In-life endpoints (skin clinical scores, ear thickness, Transepithelial Water Loss (TEWL), scratching bouts) and terminal endpoints (histopathology, total serum IgE and tissue cytokines) were measured. Further phenotyping of NC/Nga was performed by flow cytometry, gene expression analysis, and pharmacology. Results: HDM applications resulted in a more robust AD-like dermatitis in NC/Nga than BALB/c mice as evidenced by greater cha.. View more»
  

  Abstract HTML PDF