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Vera Abba
Department of Laboratory Medicine, School of Health and Biomedical Sciences, RMIT University, Victor, Australia
Publications
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Review Article
Incidence of Red Blood Cell Alloimmunisation in Transfused Myelodysplastic Syndromes Patients: A Systematic Review and Meta-Analysis
Author(s): Vera Abba and Denise E. Jackson*
Background: Red Blood Cell (RBC) alloimmunisation represents a major complication in transfused Myelodysplastic Syndrome (MDS) patients. Frequent transfusion dependency increases the risk of alloantibody formation, while Hypomethylating Agent (HMA) therapy may have immunomodulatory effects that influence this outcome. This meta-analysis aimed to evaluate the incidence of RBC alloimmunisation in transfused MDS patients and assess the impact of HMA therapy. Methods: A systematic review and meta-analysis was conducted according to PRISMA guidelines. Relevant studies were identified through PubMed, Scopus, Embase, and Google Scholar databases. Study quality was assessed using the STROBE checklist. Pooled Odds Ratios (ORs) with 95% Confidence Intervals (CIs) were calculated for alloimmunisation outcomes using a random-effects model in RevMa.. View more»