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Vamshi P
Department of Nanomedicine, Centre of Research, Albania
Publications
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Mini Review
Acquiring to Cancer Stem-Like Cells with Targeted Nano Medicine has Potential for Use in Medicine
Author(s): Vamshi P*
Multiple drug resistance (MDR) to chemotherapeutic medicines, both inherited and acquired, is a significant barrier to effective cancer treatment. P-glycoprotein and multidrug-resistance-associated proteins are examples of the ATP Binding Cassettes (ABC) transporter super family, which function as extrusion pumps. Blocking the pump proteins physically can tilt the balance between drug input and efflux toward an accumulation of the drug inside the cell, which eventually leads to cell death [1]. This is one of the most effective ways to control the active drug's efflux from the cells. Drugs approved for uses other than treating cancer included MDR modulators, commonly referred to as Chemosensitizers. However, their clinical use is limited by their toxicity, side effects, and low solubility at levels needed to reverse MDR. Prior studies have demonstrated that medications from the sel.. View more»