Biology and Medicine

Cardiology Division, Shenzhen Institutes of Research and Innovation, The University of Hong Kong, Shenzhen, People's Republic of China

Publications

• Research Article   
  The Effect of Glucagon-like Peptide-1 Receptor Agonist (GLP1RA) on Hypertensive Induced Heart Failure with Preserved Ejection Fraction and Hypertensive Cardiomyopathy
  Author(s): Zhe Yu Zhang, Song-Yan Liao, Zhe Zhen, Sijia Sun, Wing-Hon Lai, Anita Tsang and Jo Jo Siu-Han Hai*
  
  Recent preclinical data suggest that Glucagon-like Peptide-1 Receptor Agonist (GLP1RA) possesses cardioprotective properties against the pathophysiology of Hypertension (HT). We sought to unravel the potential therapeutic application of GLP1RA in a clinically relevant large animal model of hypertensive Cardiomyopathy (hCMP). We used a combination of Angiotensin II (Ang II) and Deoxycorticosterone Acetate (DOCA) pellets to induce sustained HT status and establish hCMP in porcine model. Changes in cardiac echocardiography, invasive hemodynamic parameters, neurohumoral biomarkers and inflammationrelated cytokines were investigated in 23 adult pigs, among which 6 were serving as control, 9 were induced with HT, and the remaining 8 were HT-induced with GLP1RA treatment. Eight weeks after the study initiated, HT pigs have developed sustained high Blood Pressure (BP) at both systole and dia.. View more»
  

  DOI: 10.35248/0974-8369.23.15.565

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