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Shoumen Palit
Department of Mechanical Engineering,, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
Publications
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Research Article
Bio-Engineered Plant-Produced Antigens, Self-Administered for Oral Vaccination: A Cottage Industry for Vaccines for Less Affluent Nations?
Author(s): Shoumen Palit and Austin Datta*
In this unconventional and non-systematic review, we re-present published results indicating that transgenic plants engineered to express (foreign) antigens show significant levels of mRNA (from viral coding region) and viral antigen (protein) in plant tissues (leaves). Oral administration of plant-produced antigens was immuno-stimulatory in humans, capable of conferring immunity from the viral infection (specific for the viral antigen bioengineered for expression in plant). Use of antigen-containing plant products for oral (or sublingual) administration does not require purification. The plant “paste” may be sufficient (?) for immunizing humans (and animals). Scientific evidence supports advocacy for oral administration of “raw” plant-based products (sublingual) without purification. Implementing this proposal may accelerate the pace of global vaccination and .. View more»