Pharmaceutica Analytica Acta

Department of Pharmaceutics, KLE College of Pharmacy, Karnataka, India

Biography

Roopali M. Shetake is working in Department of Pharmaceutics, KLE College of Pharmacy, Karnataka, India. His international experience includes various programs, contributions and participation in different countries for diverse fields of study. His research interests reflect in his wide range of publications in various national and international journals. He is the Editorial Board Member of many Journals and serves as a member of various associations, apart from being an author for many books.

Publications

• Research Article   
  Development and Evaluation of Curcumin Floating Tablets
  Author(s): Kishor A. Bellad, Basavaraj K. Nanjwade*, Arindam Basu Sarkar, Teerapol Srichana and Roopali M. Shetake
  
  In the present study, curcumin an anti-inflammatory agent, was first complexed with the soluplus by hot melt extrusion machine to enhance the solubility of curcumin and was formulated into floating tablets by direct compression method. Tablets were formulated using various grades of Hydroxypropyl methylcellulose (HPMC) polymers and sodium bicarbonate as gas generating agent. Preformulation and micromeritic studies were performed. The floating tablets were evaluated for their physico-chemical properties, in-vitro release, in-vivo floating property, pharmacokinetic and stability studies. Formulations were found uniform with respect to thickness (5.11 to 5.27 mm) and hardness (4.4 to 4.8 kg/cm2). The friability (0.27 to 0.53 %), weight variation (1.28-1.89%) and Drug content (97.84 to 99.46 %). The order of swelling index of HPMC was found to be K100M > K15M > K.. View more»
  

  DOI: 10.35248/2153-2435.20.11.622

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