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Ramy Arnaout
Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
Publications
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Research Article
The Coviral Portal: Multi-Cohort Viral Loads and Antigen-Test Virtual Trials for COVID-19
Author(s): Alexandra Morgan, Elisa Contreras, Michie Yasuda, Sanjucta Dutta, Donald Hamel, Tarini Shankar, Diane Balallo, Stefan Riedel, James E. Kirby, Phyllis J Kanki and Ramy Arnaout*
Objective: Regulatory approval of new over-the-counter tests for infectious agents such as SARS-CoV-2 has historically required that clinical trials include diverse groups of specific patient populations, making the approval process slow and expensive. Showing that populations do not differ in their viral loads the key factor determining test performance could expedite the evaluation of new tests. Materials and methods: We annotated 46,726 RT-qPCR-positive SARS-CoV-2 viral loads with demographics and health status, evaluated the performance of two commercially available antigen tests over a wide range of viral loads, and created an open-access web portal allowing comparisons of viral-load distributions across patient groups and application of antigen-test performance characteristics. Results: In several c.. View more»