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Omid Iravani
Legal Medicine Research Center, Tehran, Iran
Publications
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Research Article
Down-Regulation of AnnexinA5 Gene Expression in Coronary In-Stent Restenosis: A Pilot Study
Author(s): Mojtaba Baktashian, Sara Saffar Soflaei, Mansoor Salehi, Mohsen Moohebati, Omid Iravani, Mahsa Rastegar Moghaddam, Alireza Pasdar*, Majid Ghayour-Mobarhan* and Seyed Mohammad Hashemi*
Background: In- Stent Restenosis (ISR) is the Achilles heel of angioplasty. AnnexinA5 as an anticoagulant has been shown have anti-inflammatory and anti-atherosclerotic effects. Here we aim to investigating the mRNA expression of AnnexinA5 in peripheral white blood cell of patients with in-stent restenosis. Methods: Patients with the history of coronary stent implantation who candidate for re-angiography were entered the study and allocated into two groups according the results of re-angiography; in-stent restenosis (stenosis ≥ 50% in stent) and non-in-stent restenosis (stenosis<50% in stent). Total RNA of WBC was extracted and cDNA was synthesized using commercial kits. AnnexinA5 expression was assessed with real time PCR and TaqMan probe and reported in relation with GAPDH as a housekeeping gene. Results: A.. View more»