Journal of Data Mining in Genomics & Proteomics

Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia

Publications

• Research Article   
  Structural, Functional Annotation of Complete Protein Coding Regions of TYLCV and Molecular Docking of Rep and Ren proteins with Resistance Genes Ty-2, Ty-5, and Yy-6 to Module Precise Molecular Auditing of Pathogen
  Author(s): Muhammad Tayyab, Sarmad Frogh Arshad*, Abdul Malik, Muhammad Usman, Asif Saleem, Imran Ahmad Khan, Hasan Junaid Arshad, Asma Shah Rukh and Muhammad Tahir
  
  Tomato Yellow Leaf Curl Virus (TYLCV), a single-stranded DNA begomovirus, belongs to the family Geminiviridae, which encodes six Open Reading Frames (ORFs). Host pathogen interaction studies revealed different resistance genes (Ty-2, Ty-5, and Ty-6) whose binding affinities and interaction patterns are still unclear against TYLCV. It is a dire need to understand the ORFs of TYLCV at the computational level to get insight into their electrostatic interaction, hydrogen bonding patterns, and binding affinities with resistance genes. In the recent study, comprehensive proteomic analyses of all encoded regions of TYLCV were performed, and the results revealed that C1 (Rep) protein was present at 30.4% in the nucleus, 34.8% in the mitochondria, and 26.1% in the cytoplasm. The 65.2% area of the mitochondria, with a 34.8% g area of the nucleus, was occupied by the C3 (Ren) factor, while the C.. View more»
  

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