Review Article
Diagnosis of Neurosyphilis through Treponemal Methods Based on Hemagglutination in Cerebrospinal Fluid in PLWHIV and without HIV: Systematic Review
Author(s): Beatriz Pereira de Azevedo*, Isabelle de Carvalho Rangel, Ricardo de Souza Carvalho, Mariana Munhoz Rodrigues, Luciane Cardoso dos Santos Rodrigues, Leonardo Lora-Barraza and Fernando Raphael de Almeida Ferry

Neurosyphilis (NS) is the severe form of syphilis caused by the invasion of Treponema pallidum subspecies pallidum in the Central Nervous System (CNS). The laboratory diagnosis is based on the analyses of Cerebrospinal Fluid (CSF) with the VDRL, considered “gold standard”, despite recent studies reporting low sensitivity (40%- 70%). The treponemal tests based on hemagglutination were performed for use in serum and plasma with great diagnostic accuracy. PURPOSE: This systematic review aims to analyse original studies with treponemal tests based hemagglutination on CSF in order to verify the diagnostic accuracy of these tests in the diagnosis of NS. Methods: A search was performed in the electronic databases: EMBASE, Scielo, MEDLINE/PUBMED, LILACS, Cochrane Library, Trials and “grey literature” with the following DECS co.. View more»

DOI: 10.35841/2327-5073.22.11.269

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