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Kjell Osterberg
Department of Nanomedicine, Korea Advanced Institute of Science and Technology, Korea, Democratic People's Republic of
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Editorial
Nanoparticle-Enhanced Gene Delivery for CRISPR-Based Therapeutics
Author(s): Kjell Osterberg*
The CRISPR-Cas9 gene-editing technology has revolutionized the field of molecular biology by providing a powerful tool for precise genetic modifications. Its potential applications in therapeutic interventions, particularly for treating genetic disorders, cancer, and viral infections, have made it one of the most promising areas of biotechnology. However, one of the major challenges in the clinical application of CRISPR-based therapeutics is the efficient delivery of the CRISPR components—Cas9 proteins, guide RNAs (gRNAs), and donor DNA—into the target cells. Traditional delivery methods, such as viral vectors, are often associated with safety concerns, immune responses, and limited delivery efficiency. Nanoparticles, due to their unique properties, including biocompatibility, size-tunability, and surface modifiability, have emerged as promising alternatives for CRISPR del.. View more»