Diabetes Case Reports

Department of Medical Biochemistry, University of Abuja, Abuja-FCT, Nigeria

Publications

• Research Article   
  Modulation of Ras GTPase and IRS-1 Activities by Spermine in Type 2 Diabetes: A Study Using Goto Kakizaki Rat Model
  Author(s): Boniface O. Ogar, Azubuike I. Okafor, Kenneth C. Nwachukwu, Bassey A. Inyang, Lukman A. Alli* and Michael P. Okoh*
  
  In this study, we investigated the biochemical relationship between spermine, Ras GTPase activity, Insulin Receptor Substrate-1 and how they possibly affect insulin signaling and blood glucose concentrations using Goto Kakizaki (GK) rats as a model for type 2 diabetes mellitus. Type 2 diabetes mellitus is characterized by impaired insulin signaling and glucose dysregulation. Ras GTPases play a crucial role in regulating downstream signaling pathways, cycling between active GTP-bound and inactive GDP-bound states. GK rats were administered varying doses of spermine (6.25-25.00 mg/kg body weight) for six weeks. Spermine treatment enhanced Ras GTPase activity, associated with elevated Guanine Nucleotide Exchange Factor (GEF) activity and reduced GTPase-Activating Protein (GAP) activity. This upregulation corresponded with increased IRS-1 concentrations and improved glucose regulation. No.. View more»
  

  Abstract PDF