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Kazumi Fujioka
Department of Radiology, Nihon University School of Medicine, Tokyo, Japan
Publications
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Review Article
Focal nodular hyperplasia-like lesions after chemotherapy with oxaliplatin or cyclophosphamide in cancer survivors: along with differentiation from liver metastases
Author(s): Kazumi Fujioka*
Recently the development of Focal Nodular Hyperplasia (FNH)-like lesions after chemotherapy with oxaliplatin or cyclophosphamide in patients with cancers has emerged. Meanwhile, the role of gadoxetic acid (Gd-EOB-DTPA) MRI in the differential diagnosis of chemotherapy-induced FNH-like lesions and liver metastases has been established. In this article, the current knowledge and trends of FNH-like lesions after chemotherapy with oxaliplatin or cyclophosphamide along with the differentiation from liver metastases using Gd-EOB-DTPA MRI in cancer survivors have been reviewed. Cyclophosphamide-based chemotherapy in patients with breast cancer should be regarded as a probable factor for the development of FNH-like lesions due to Sinusoidal Obstruction Syndrome (SOS) involvement. Based on the evidence, compared to oxaliplatin-based chemotherapy group, the shorter interval between the completi.. View more»