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Kazumi Fujioka
Department of Radiology, Nihon University School of Medicine, Tokyo, Japan
Publications
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Review Article
Oxaliplatin-Related Hepatic Sinusoidal Obstruction Syndrome: Updated Biological Pathway Analysis
Author(s): Kazumi Fujioka*
Oxaliplatin is a backbone drug of many regimens for colorectal cancer and colorectal liver metastasis. The author previously described a thorough review of the literature on oxaliplatin-induced hepatic complications focusing on Sinusoidal Obstruction Syndrome (SOS), Nodular Regenerative Hyperplasia (NRH), and Focal Nodular Hyperplasia (FNH) in patients with colorectal cancer and colorectal liver metastasis and emphasized Liver Stiffness Measurement (LSM) as a novel predictor by elastography, recently reviewed the mechanism of oxaliplatin-induced SOS along with potential therapeutic strategy. In this article, the current knowledge and trends of oxaliplatin-induced SOS along with updated biological pathway analysis have been reviewed. Additionally, an association between oxaliplatin-induced SOS and atherosclerotic status has been described. It is plausible that oxaliplatin-.. View more»