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Kazumi Fujioka
Department of Radiology, Nihon University School of Medicine, Tokyo, Japan
Publications
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Review Article
Polygenic Risk Score in NAFLD/NASH-Associated Hepatocellular Carcinoma Along With Multifactorial Process
Author(s): Kazumi Fujioka*
The prevalence and incidence of Non-Alcoholic Fatty Liver Disease (NAFLD) is increasing due to the epidemics of obesity and Type 2 Diabetes Mellitus (T2DM). Recently, a link between NAFLD and hypertension along with new genetic expression has been identified. NAFLD is a multisystem disease and is associated with hepatic and extrahepatic diseases. The author previously described that in addition to the epidemiological and single genetic factors, the study of combined effect of the variants may be attributed to the risk stratification in NAFLD/NASHrelated hepatocellular carcinoma (HCC) and also suggested that the stratification of the risk of NAFLD related HCC especially non-cirrhotic HCC based on the characteristic clinical and genetic evidence may contribute to the prevention, prediction, and surveillance. The risk factors and multifactorial process include obesi.. View more»