Department of Laboratory Medicine, School of Health and Biomedical Sciences, RMIT University, Victor, Australia
Review
Effectiveness of Pathogen Reduction Techniques in Fresh Blood Products for Enhancing Community Health: A Systematic Review and Meta-Analysis
Author(s): Jingchun Gao*
Transfusions of fresh blood products are a vital part of modern medical care, but they still carry the risk of transmitting infections. To address this, Pathogen Reduction Technologies (PRTs) have been developed as an added safety layer by deactivating potential infectious agents in blood components. This systematic review and meta-analysis, conducted in line with PRISMA guidelines, examined how effectively these technologies improve transfusion safety and public health. A thorough search of PubMed, Scopus, and Google Scholar identified peer- reviewed, full-text studies published in English over the last decade. Eligible studies compared pathogen-reduced blood products with standard ones. Data on Transfusion-Transmitted Infections (TTIs) and Transfusion-Related Adverse Events (TRAEs) were extracted and analysed using a random-effects model in RevMan 5.4, with pooled Odds Ratios (ORs) .. View more»