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Grinberg I
The Institute of Nanotechnology and Advanced Materials, Department of Chemistry, Bar-Ilan University, Ramat-Gan 5290002, Israel
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Research
Targeted Delivery of CBD-Loaded Poly (RGD) Proteinoid Nanoparticles for Antitumor Therapy
Author(s): Lugasi L, Grinberg I and Margel S*
Background: Targeted nanoparticle (NP)-based drug delivery systems enable administration of non-soluble drugs and enhance their efficacy. The arginine-glycine-aspartic acid (RGD) motif is a known recognition site of integrins, and RGD receptors are overexpressed in tumors and their neovasculature and can be used as targets for tumor treatment. Cannabidiol (CBD), the main non-psychotropic phytocannabinoid of Cannabis sativa, exhibits various therapeutic effects and has antitumor properties. Encapsulation of CBD within poly(RGD) (P(RGD)) proteinoid NPs can overcome the poor solubility and bioavailability of CBD and target it to tumors in vivo. Methods: P(RGD) proteinoid polymer was synthesized from D- and L-amino acids by thermal step-growth polymerization. CBD was encapsulated within the proteinoid NPs by self-assembly process.. View more»