Clinics in Mother and Child Health

Obstetric High-Risk Group, Brazil

Publications

• Research Article   
  The Effect of Omega/Heparin Association on the Obstetric Outcome of Pregnant Women with Thrombophilia: A Pilot Study
  Author(s): Marcelo Lopes de Souza Mendes, Lucas Campos Amaral, Daniel Henrique de Siqueira Dornelas, Lucas Palhares Baeta Duarte, Giovanna Carvalho Silva, Mariana Pinto Sirimarco, Alexander Cangussu Silva, Clarissa Rocha Panconi, Larissa Milani Coutinho, Patrícia de Oliveira Lima, Sirleide Corr�?ªa Rangel, Flávia Lima Miranda, Maria Luiza Braga Leal, Geovana Tiango Gabriel, Gabriel Duque Pannain, Marcus Gomes Bastos and Juliana Barroso Zimmermmann*
  
  Introduction: It is possible assuming that thrombophilias can change the optimal placental function, as well as lead to infarctions, impaired maternal-fetal exchange mechanisms and even to fetal death. Placental hypoxia determines a vicious cycle comprising oxidative stress, vasoconstriction and impaired fetal oxygenation. Prophylactic heparin use throughout pregnancy has been recommended in some thrombophilia cases because it acts on the coagulation cascade. However, although heparin does not cross the placental barrier and is safe for the fetus, not all patients can use it. Its administration route (parenteral) is not practical and even its prophylactic use is not necessarily harmless, as seen in different thrombocytopenia, gastrointestinal and cerebral bleeding reports. Thus, finding clinical alternatives for these pregnant women would help significantly improving .. View more»
  

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