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Dr. Prince Ahad
Department of Pharmacognosy and Phytochemsitry, Khalsa College of Pharmacy, Amritsar, Punjab-143002, India
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Research
Formulation and Evaluation of Butenafine hydrochloride loaded Niosomes for the treatment of superficial Dermatophytosis
Author(s): Dr. Prince Ahad*
The present study aims to prepare and optimize Butenafine hydrochloride niosomes utilizing varying concentrations of surfactant and cholesterol as a lipid for topical application. Thin film hydration method was employed to optimize the niosomes using cholesterol as a lipid and span series as surfactant. The optimized niosomes was assessed for particle size, poly dispersity index, entrapment efficacy, and the invitro drug release study. The particle size of prepared niosomes was found within the range of 236.2 to 486.4. Zeta potential was found in range between -20.2 to -39.0 mV with entrapment efficacy ranging from 80.558±0.448 to 88.492±0.206%. The in vitro studies demonstrated that optimized niosomes showed sustained drug release for 6 hours (92.77%), and follows Higuchi Model which is much improved than the marketed formulation of BT HCl which rel.. View more»