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Aideen Long
Department of Clinical Medicine, Trinity College Dublin and Trinity Translational Medicine Institute, Dublin, Republic of ireland
Publications
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Research Article
L-plastin Expression in HCT 116 Colorectal Cells Increases Migration and ROS in an NADPH Oxidase-Dependent Manner
Author(s): Eilis Foran, Michael Freeley and Aideen Long*
Objective: L-plastin is an action-bundling protein normally expressed in cells of haemopoietic origin but is also associated with malignant transformation. Aberrant expression of L-plastin expression correlates with tumour stage in colorectal cancers, and ectopic expression of L-plastin in colon cancer cell lines increases proliferation and migration. L-plastin is inducibly phosphorylated on Ser5 in response to a range of stimuli but the role of phosphorylated L-plastin in colon cancer cells has not been characterised. The aim of this study was to analyse the effect of L-plastin Ser5 phosphorylation on HCT 116 colon cancer cell proliferation and migration. Methods: Wild-type L-plastin or a Ser5 L-plastin mutant where serine was exchanged to a non-phosphorylatable alanine was expressed in HCT 116 cells. Cell p.. View more»