Journal of Carcinogenesis & Mutagenesis

Zhenhua Du

Publications

• Research Article
  The Edible Adlay Seed Oil Containing Cinnamaldehyde and Gingerol Prevents DMBA/TPA-Induced Skin Carcinogenesis by Cooperative Ablation of Lipid Rafts
  Author(s): Yaqiu Zheng, Shengnan Geng, Mingjing Meng, Zhenhua Du, Jingjing Yao, Zibo Li, Qun Zhang, Zhenzhen Zhang, Yongjian Duan and Gangjun DuYaqiu Zheng, Shengnan Geng, Mingjing Meng, Zhenhua Du, Jingjing Yao, Zibo Li, Qun Zhang, Zhenzhen Zhang, Yongjian Duan and Gangjun Du
  
  It is known that food intake was associated with decreased risk of cancer, we prepared a compounded adlay seed oil (C-ASO) containing 0.5% cinnamaldehyde and 1% 6-gingerol and evaluated the preventive effects of the oral C-ASO on DMBA/TPA-induced skin carcinogenesis. In contrast to untreated carcinogenic mice, skin tumor incidence and multiplicity were decreased to some extent in single ASO-, cinnamaldehyde- and gingerol-treated mice, whereas the oral C-ASO almost completely reduced susceptibility to skin carcinogenesis by cooperative ablation of enhanced lipid rafts, drastically suppressed phosphatidylinositol 3-Kinases (PI3K)/protein kinases A (Akt) signaling and decreased levels of nuclear transcription factor-kappa B (NF-κB) and cyclin D1 which reduced skin epithelial proliferation and epithelial-mesenchymal transition (EMT) during tumor genesis. This work supports C-ASO as .. View More»
  DOI: 10.4172/2157-2518.1000302

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