Biology and Medicine

Zahra Akbari Jonoush

Publications

• Research Article
  Design and Manufacturing of Electromechanical Chip for Rapid Measurement of IgG1 Antibody in Cell-Culture Supernatant
  Author(s): Azam Rahimpour, Fatemeh Yazdian, Zahra Akbari Jonoush, Masoumeh Rajabibazl and Meisam OmidiAzam Rahimpour, Fatemeh Yazdian, Zahra Akbari Jonoush, Masoumeh Rajabibazl and Meisam Omidi
  
  In this study, we have used arrays of piezoresistive nanomechanical membrane resonators (NMRs) to detect IgG1 antibody. The NMR consists of a membrane suspended by four piezoresistive sensing components. Unlike conventional cantilever mass sensors, our sensors retain a uniform mass sensitivity over the membrane surface. According to the experiments, it was revealed that NMRs have mass sensitivities in the order of 25 Hz/pg in air and 1.8 Hz/pg in liquid. This matter allows them to detect IgG1 over a wide range of concentrations from 100 pg/mL to 10 μg/mL in a background of human serum albumin (HSA) at 1 mg/ml. This indicates the fact that the self-sensing NMR approach is beneficial for detecting disease markers. Moreover, the performance of the NMR was compared with other detection methods, and the results indicated a better performance for NMR. .. View More»
  DOI: 10.4172/0974-8369.1000340

  Abstract PDF