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Witold Lojkowski
Witold Lojkowski
Laboratory of Nanostructures for Photonic and Nanomedicine, Institute of High Pressure Physics,
Polish Academy of Sciences, Warsaw
Poland
Publications
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Research Article
Mesoporous Silica Materials in Drug Delivery System: pH/Glutathione- Responsive Release of Poorly Water-Soluble Pro-drug Quercetin from Two and Three-dimensional Pore-Structure Nanoparticles
Author(s): Khaled E.A. AbouAitah, Ahmed A. Farghali, Anna Swiderska-Sroda, Witold Lojkowski, AbdelFattah M. Razin and Mohamed H. KhedrKhaled E.A. AbouAitah, Ahmed A. Farghali, Anna Swiderska-Sroda, Witold Lojkowski, AbdelFattah M. Razin and Mohamed H. Khedr
Quercetin (Quer) is one of natural products (pro-drugs), presenting pharmacological properties such as: anti-oxidant, anti-inflammatory and anti-cancer activities. However, poor solubility of the Quer causes its poor bioavailability, and consequently reduces its therapeutic efficiency. To manage this problem, different actions are undertaken, among other drug delivery systems (DDSs) are investigated. The objective of present work was to evaluate potential applications of silica nanoparticles as quercetin nanocarriers and to investigate the influence of pH conditions and glutathione (GSH, as non-redox process) concentrations on quercetin release. Two types of mesoporous silica nanoparticles: MCM-41 (2D arrangement of pores) and KCC-1 (3D arrangement of pores) were synthesized and then functionalized by amino-groups. Immersion-evaporation method was use.. View More»
DOI: 10.4172/2157-7439.1000360