William Newman
Tanzania
Research Article
Incidence of Hypocalcemia in Patients with Post-Menopausal Osteoporosis or Cancer Skeletal Related Events after Denosumab in Comparison to Zoledronic Acid in a Community Hospital Setting
Author(s): Sunita Sharma and William NewmanSunita Sharma and William Newman
Introduction: Denosumab, a monoclonal antibody, was recently approved by US Food and Drug Administration for treatment of postmenopausal osteoporosis and cancer skeletal related events (SRE). A variable incidence of hypocalcemia (5.5-13%) has been reported with denosumab as compared to the commonly used bisphosphonate, zolendronic acid (3.4-6%).
Methods: We reviewed the medical records of patients who received either denosumab or zoledronic acid in a community hospital setting to determine the incidence of hypocalcemia in patients with post-menopausal osteoporosis or cancer SRE.
Results: We found hypocalcemia with both denosumab and zoledronic acid post-injection but roughly twice as high in the denosumab group. Since, calcium levels were not obtained at the time of peak effect of treatment in every patient, we believe.. View More»
DOI:
10.4172/2329-6887.1000176