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Vassilios Karavelidis
Vassilios Karavelidis
Greece
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Research Article
New Biocompatible Aliphatic Polyesters as Thermosensitive Drug Nanocarriers. Application in Targeting Release Pharmaceutical Systems for Local Cancer Treatment
Author(s): Vassilios KaravelidisVassilios Karavelidis
In the present study a new drug delivery system for the treatment of local cancer was developed. Two aliphatic polyesters namely poly(propylene adipate) (PPAd) and poly(propylene pimelate) (PPPim), were used as carriers in order to prepare nanoparticles loaded with paclitaxel. The starting materials as well as the nanoparticles were characterized with DSC, SEM and WAXD techniques. The nanoparticles had a mean particle size of 160-190nm and characterized for drug loading content, efficiency and in vitro dissolution at 37ºC and 42ºC in two different pH buffer solutions (pH 7.4 and pH 6.0). Results showed enhanced release rate of paclitaxel at 42ºC compared to 37ºC in both pH conditions. The degree of crystallinity plays also an important role to paclitaxel release. The cytotoxicity of the prepared paclitaxel/ polyester nanoparticles was stud.. View More»
DOI: 10.4172/2157-7439.1000134