Biology and Medicine

Umasankar Kulundaivelu

Publications

• Research Article
  Effect of Atorvastatin on Pharmacology of Sitagliptin in Streptozotocin-Nicotinamide Induced Type-II Diabetes in Rats
  Author(s): Venkateshwarlu Eggadi, Sharvana Bhava Bandaru Sheshagiri, Adukondalu Devandla, NagaraniDasi, Umasankar Kulundaivelu, Shiva Kumar Revoori and Sahith Reddy KesireddyVenkateshwarlu Eggadi, Sharvana Bhava Bandaru Sheshagiri, Adukondalu Devandla, NagaraniDasi, Umasankar Kulundaivelu, Shiva Kumar Revoori and Sahith Reddy Kesireddy
  
  Prolonged type 2 diabetes mellitus (Type2DM) may lead to high risk of cardiovascular disease (CVD) requiring a global therapeutic approach. Statin therapy has proven its efficacy in reducing CVD events in Type2 DM patients. Dipeptidyl peptidase-4 inhibitors (gliptins), which are increasingly used to target hyperglycemia. In the present study type 2 DM in rats by i.p. Administration of Streptozotocin (STZ); (60 mg/kg) -Nicotinamide (120 mg/kg). Diabetes induced rats were divided into groups and treated with Sitagliptin alone and in combination with atorvastatin for 7 days. Blood samples were collected by retro orbital puncture. Mean glucose concentration was measured by GODPOD method using commercial glucose kits and sitagliptin in plasma was estimated by RP-HPLC method using methanol: water (60:40 v/v, containing 10 mM Tris and 10 mM Triethylamine) was adj.. View More»
  DOI: 10.4172/0974-8369.1000225

  Abstract PDF