Journal of Pharmacogenomics & Pharmacoproteomics

Tapola Anastasia

Publications

• Research Article
  The Cholesteryl Ester Transfer Protein (CETP) Taqib and I405V Gene Polymorphisms and Statin Treatment
  Author(s): Bousoula Eleni, Kolovou Vana, Boutsikou Maria, Tapola Anastasia, Perrea Despoina and Kolovou GenovefaBousoula Eleni, Kolovou Vana, Boutsikou Maria, Tapola Anastasia, Perrea Despoina and Kolovou Genovefa
  
  Background: CETP (cholesterol ester transfer protein) is a plasma protein that facilitates the transport of cholesteryl esters and triglycerides between the lipoproteins. It is composed mainly at the liver and it collects triglycerides from chylomicrons and VLDL and exchanges them for cholesteryl esters from HDL. By this mean, very dense LDL molecules are being formed. The latter are very atherogenetic factors. The gene encoding CETP is located on the long (q) arm of chromosome 16 at position 21. It has been found that at least two polymorphisms in this gene, TaqIB (with B1B1, B1B2 and B2B2 genotypes) and I405V (with II, IV and VV genotypes), have been associated with different response to statin treatment. Aim: The aim of this study was to investigate a probable correlation of the aforementioned CETP gene polymorphisms with better or worse response to two specific statins: simvast.. View More»
  DOI: 10.4172/2153-0645.1000168

  Abstract PDF