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Tania Sultana
Tania Sultana
Bangladesh
Publications
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Research Article
Fluorescence Spectroscopic Study of Interaction between Olanzapine and Bovine Serum Albumin
Author(s): Mohammad A Rashid, Sikder Nahidul Islam Rabbi, Tania Sultana, Md. Zamil Sultan and Md. Zakir SultanMohammad A Rashid, Sikder Nahidul Islam Rabbi, Tania Sultana, Md. Zamil Sultan and Md. Zakir Sultan
The binding capacity of an antipsychotic drug, olanzapine with bovine serum albumin (BSA) was studied. The experiment was designed to investigate the interaction between olanzapine and BSA using fluorescence spectroscopy at different temperatures (298 K and 308 K). Fluorescence quenching constant was determined from Stern-Volmer equation. Van’t Hoff equation was used to determine the thermodynamic parameters such as free energy (ΔG), enthalpy (ΔH) and entropy (ΔS). A strong quenching was observed in the fluorescence spectrum. The quantitative analysis revealed that olanzapine bound with BSA via a dynamic quenching through hydrophobic interactions, where binding constant Kb at 280 nm was 10.28x104 μM-1 and 10.739x104 μM-1 at 298 and 308 K, whereas it was 19.31x104 μM-1 and 18.923x104 μM-1 when the study was conducted at 293 nm, respectively. The numb.. View More»
DOI: 10.4172/2153-2435.1000408