Journal of Stem Cell Research & Therapy

Takashi Otsuka

Publications

• Research Article
  Hypoxic Preconditioning Increases the Neuroprotective Effects of Mesenchymal Stem Cells in a Rat Model of Spinal Cord Injury
  Author(s): Takeshi Imura, Mayumi Tomiyasu, Naofumi Otsuru, Kei Nakagawa, Takashi Otsuka, Shinya Takahashi, Masaaki Takeda, Looniva Shrestha, Yumi Kawahara, Takahiro Fukazawa, Taijiro Sueda, Keiji Tanimoto and Louis YugeTakeshi Imura, Mayumi Tomiyasu, Naofumi Otsuru, Kei Nakagawa, Takashi Otsuka, Shinya Takahashi, Masaaki Takeda, Looniva Shrestha, Yumi Kawahara, Takahiro Fukazawa, Taijiro Sueda, Keiji Tanimoto and Louis Yuge
  
  The functional deficit caused by Spinal Cord Injury (SCI) is clinically incurable and current treatments have limited effects. Previous studies have suggested that cell-based therapy using Mesenchymal Stem Cells (MSCs) pre-treated with drugs or gene transfection have possible therapeutic effects. Hypoxic preconditioning is one of the most likely treatments of cell-based therapy without altering genes; however, few reports are available about Hypoxia-Preconditioned MSCs (H-MSC) transplantation for SCI. Here we demonstrate the therapeutic potential of H-MSC transplantation using SCI model rats. H-MSC expressed significantly higher mRNA levels of vascular endothelial growth factor-1 and carbonic anhydrase IX, hypoxia inducible genes. H-MSC transplantation resulted in remarkable functional improvement in the SCI model rats compared to no transplantation. Expression of brainderived neurotr.. View More»
  DOI: 10.4172/2157-7633.1000375

  Abstract PDF