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Sushila Rathee
Sushila Rathee
India
Publications
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Research Article
Statistical Design for Optimization and Determination of Tizanidine Hcl using Folin-Ciocalteu (Fc) as Chromogenic Reagent
Author(s): Permender Rathee, Kamal Dua, Sushila Rathee and Vikash KumarPermender Rathee, Kamal Dua, Sushila Rathee and Vikash Kumar
A simple, sensitive spectrophotometric method has been developed for quantitative determination of Tizanidine Hydrochloride in bulk and pharmaceutical formulations with application of factorial design. In this method, Tizanidine Hydrochloride is made to react with Folin-Ciocalteu (FC) reagent under alkaline conditions forming a blue chromogen having absorption maximum at 663 nm. Beer’s law was obeyed in the concentration range of 4-36 μg/ml. Results of the analysis were validated as per ICH guidelines and by recovery studies. A 3-factor, 3-level statistical design (Box-Behnken) was used to derive a second-order polynomial equation to construct contour plots for prediction of response. Independent variables studied were the FC-reagent (X1), sodium carbonate (X2) and drug concentration (X3) and t.. View More»
DOI: 10.4172/2153-2435.1000307