Journal of Carcinogenesis & Mutagenesis

Srinivas Bharath MM

Publications

• Research Article
  Role of Concurrent Methylation Pattern of MGMT, TP53 and CDKN2A Genes in the Prognosis of High Grade Glioma
  Author(s): Jeru-Manoj Manuel, Debarati Ghosh, Narasinga Rao KVL, Sibin MK, Venkatesh HN, Lavanya Ch, Arati S, Dhananjaya I Bhat, Srinivas Bharath MM and Chetan GKJeru-Manoj Manuel, Debarati Ghosh, Narasinga Rao KVL, Sibin MK, Venkatesh HN, Lavanya Ch, Arati S, Dhananjaya I Bhat, Srinivas Bharath MM and Chetan GK
  
  Objective: High grade glioma (HGG) patients show poor prognosis and survival. Promoter methylation of MGMT gene induces altered methylation profile across cell cycle regulating genes. Correlating the promoter methylation status between important tumor suppressor genes could enhance the current understanding of glioma progression. Methods: We analysed individual and concurrent methylation statuses’ of three tumor suppressor genes, MGMT, TP53 and CDKN2A in different types of HGG and their probable effect on progression free survival. MS-PCR was used to analyse the methylation statuses from 48 HGG tumor samples. Results: Promoter methylation was observed in 89.5% (43/48) of our cohort in atleast one of the genes, most frequent in MGMT (75%), followed by CDKN2A (35.4%) and TP53 (29.2%). MGMT methylation and TP53 unmethylation individually were significant (p=0.001 and .. View More»
  DOI: 10.4172/2157-2518.1000250

  Abstract PDF