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Solomon Habtemariam
Solomon Habtemariam
Director of Pharmacognosy Research Laboratories and Herbal Analysis Services UK,
Chatham-Maritime, Kent ME4 4TB
Publications
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Research Article
Methodology for Rapid Isolation of Moringin: Potential Anticancer Compound from the Seeds of Moringa stenopetala
Author(s): Solomon HabtemariamSolomon Habtemariam
The seeds of Moringa stenopetala which are known to be rich sources of glucosinolates, primarily glucomoringin, have been shown to have limited anticancer effects when tested in vitro. In the present study, however, the water extract of the seeds obtained following defatting by hexane displayed potent cytotoxic activity against HepG2 (IC50, 6.28 ± 0.55 μg/ml) and the SH-SY5Y human neuroblastoma (IC50, 9.81 ± 1.30 μg/ml) cells. The methanol extract displayed a weak cytotoxic activity against the HepG2 human hepatocellular cancer cells when tested upto 500 μg/ml, while extraction with hexane yielded the non-cytotoxic fixed oil which fatty acid composition was primarily oleic acid (75%). By monitoring the constituents of the water extract by HPLC and a one-step combiflash chromatographic system using C-18 silica gel system, the principal active constituent (glucomo.. View More»
DOI: 10.4172/2153-2435.1000558