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Sohini Walia
Sohini Walia
India
Publications
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Research Article
Characterization of 99mTc-Resveratrol as a Cancer Targeting Radiopharmaceutical: An In Vitro study
Author(s): Rozy Kamal, Vijayta D Chadha, Sohini Walia and Dhawan DKRozy Kamal, Vijayta D Chadha, Sohini Walia and Dhawan DK
Introduction: The present study describes the radio-synthesis, chemical characterization and bio-evaluation of 99mTc-resveratrol as a diagnostic imaging probe in radionuclide imaging of cancer using single photon emission computed tomography (SPECT). Methods: Resveratrol, a potent chemopreventive natural phytoalexin was labeled with Technetium (99mTc).Radiolabeling efficiency, stability in vitro, cytotoxicity in rat RBCs and in HT29 colon cancer cells along with cellular internalization and binding characteristics were investigated. Results: The radiochemical purity of synthesized radio-complex, 99mTc-resveratrol was >85%. 99mTcresveratrol was stable upto 2 hours at room temperature between pH ranges 5-7. 99mTc-resveratrol, containing resveratrol up to a concentration of 20 μM was found to be nontoxic to both HT 29.. View More»
DOI: 10.4172/2157-2518.1000253