Indexed In
- Genamics JournalSeek
- JournalTOCs
- CiteFactor
- Ulrich's Periodicals Directory
- RefSeek
- Hamdard University
- EBSCO A-Z
- Directory of Abstract Indexing for Journals
- OCLC- WorldCat
- Publons
- Geneva Foundation for Medical Education and Research
- Euro Pub
- Google Scholar
Useful Links
Share This Page
Journal Flyer
Open Access Journals
- Agri and Aquaculture
- Biochemistry
- Bioinformatics & Systems Biology
- Business & Management
- Chemistry
- Clinical Sciences
- Engineering
- Food & Nutrition
- General Science
- Genetics & Molecular Biology
- Immunology & Microbiology
- Medical Sciences
- Neuroscience & Psychology
- Nursing & Health Care
- Pharmaceutical Sciences
Silvia Reina
Silvia Reina
Argentina
Publications
-
Research Article
Autoantibodies against Muscarinic Acetylcholine Receptor on Exocrine Glands in Sjogren Syndrome
Author(s): Silvia Reina and Enri BordaSilvia Reina and Enri Borda
These investigations demonstrate that serum antibodies against muscarinic acetylcholine receptors (mAChR) in primary Sjögren syndrome (pSS) and associated Sjögren syndrome (aSS) bind and activate both cholinergic receptors of M3 in salivary gland and M1 in neonatal myocardium and in the cerebral frontal cortex area subtypes; triggering the production of the second messengers and proinflammatory mediators related to mAChR activation. In this way the cholinergic autoantibodies damages these receptors, which thus starts acting as an antigen. On this basis M3 and M1 mAChR IgG can be considered new markers of pSS/aSS allowing the differentiation between dry eye and mouth of autoimmune and non-autoimmune nature. Given that cholinergic autoantibodies also.. View More»
DOI: 10.4172/2161-1122.1000265